Tatematsu, Yukako; Khan, Qalbi; Blanco, Tomas; Bair, Jeffrey A.; Hodges, Robin R.; Masli, Sharmila; Dartt, Darlene A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-16)
Thrombospondin-1-deficient (TSP-1−/−) mice are used as an animal model of Sjögren’s
Syndrome because they exhibit many of the symptoms associated with the autoimmune type of dry
eye found in primary Sjögren’s Syndrome. This type of dry eye is linked to the inflammation of
the lacrimal gland, conjunctiva, and cornea, and is thought to involve dysfunction of the complex
neuronal reflex arc that ...